Engineered Aerosol Medicine and Drug Delivery Methods for Optimal Respiratory Therapy
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چکیده
منابع مشابه
Engineered aerosol medicine and drug delivery methods for optimal respiratory therapy.
The human lung is an effective route for noninvasive drug delivery because it provides a large surface area for rapid absorption, a minimal physical barrier, an absence of extreme pH and metabolism, no first-pass liver, a rich blood supply, and poor bioavailability of oral drugs. The physical and electrical properties of active pharmaceutical ingredient and excipient interactively influence 5 e...
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INTRODUCTION Every year, approximately 2,500 children are admitted to the pediatric intensive care unit (PICU) at the Children’s Hospital of Pittsburgh at the University of Pittsburgh Medical Center alone [1]. Respiratory illnesses are one of the leading causes of admission [1]. For children with acute respiratory illnesses, inhaled medications are a common method of treatment, as this allows p...
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Equivalent clinical results can be achieved from any delivery device, providing the patient can use it correctly. Selection of the appropriate device for each patient requires consideration of multiple factors. Inhaler technique should be demonstrated by the patient at each visit, assessed by the health-care provider, and where necessary, training to optimise aerosol delivery should be repeated...
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Engineered polymers have been utilized for developing advanced drug delivery systems. The development of such polymers has caused advances in polymer chemistry, which, in turn, has resulted in smart polymers that can respond to changes in environmental condition such as temperature, pH, and biomolecules. The responses vary widely from swelling/deswelling to degradation. Drug-polymer conjugates ...
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Cytotoxicity, low water solubility, rapid clearance from circulation, and off-target side-effects are common drawbacks of conventional small-molecule drugs. To overcome these shortcomings, many multifunctional nanocarriers have been proposed to enhance drug delivery. In concept, multifunctional nanoparticles might carry multiple agents, control release rate, biodegrade, and utilize target-media...
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ژورنال
عنوان ژورنال: Respiratory Care
سال: 2014
ISSN: 0020-1324,1943-3654
DOI: 10.4187/respcare.03634